Royal Canadian Air Force Airbus CC-150 304/MRTT (15005) leaving Palermo eastbound. The aicraft is flying with (at least) two RCAF McDonnell Douglas CF-188 “Hornet” (188767 & 188932).
We don’t know their destination.
Here you can find a post of facebook page “Sicilia in volo” with some photos of the aircraft in Palermo.